Yanchao Li ORCID ID: 0000-0002-2884-9829
The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for respiratory failure
Patients with COVID-19
Yan-Chao Li 1 *, Wan-Zhu Bai 2, Tsutomu Hashikawa 3
1Norman Bethune College of Medicine, Jilin University, Changchun, Jilin Province, China 130021
2 Institute of Acupuncture and Toxicology, Chinese Academy of Medical Sciences, Beijing, China 100700
3 Department of Advanced Technology Development, RIKEN Brain Science Institute, Saitama, Japan 0198-351
Running title: Neuroinvasive potential of SARS-CoV-2
Page number: 10; Digits: 0; Words: 1650
* Correlation with:
Yan-Chao Li, Norman Bethune School of Medicine, Jilin University, Changchun, Jilin Province, China, 130021. E-mai l: liyanchao@jlu.edu.cn
abstract
Following severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East hemorrhagic respiratory syndrome (MERS-CoV), another highly pathogenic coronavirus, SARS-CoV-2 (formerly known as 2019-nCoV was)
This article has been accepted for publication and has undergone full peer review, but has not undergone the copyediting, typing, pagination, and proofreading process that may result in discrepancies between this version and the recorded version. Please cite this article as doi: 10.1002/jmv.25728.
It emerged in Wuhan, China in December 2019 and quickly spread around the world. This virus shares highly homologous sequence with SARS-CoV, and causes acute, highly fatal pneumonic pneumonia (COVID-19) with clinical signs similar to those reported for SARS-CoV and MERS-CoV. The most characteristic symptom of patients with COVID-19 is respiratory distress, and most patients admitted to the intensive care unit cannot breathe on their own. In addition, some patients with COVID-19 also showed neurological symptoms such as headache, nausea and vomiting.
Increasing evidence suggests that coronaviruses are not always confined to the respiratory tract and may also attack the central nervous system causing neurological diseases. SARS-CoV infection has been reported in the brain of both patients and laboratory animals, where the brainstem was heavily infected. In addition, some viruses have been shown to be able to spread via a synapse-linked pathway to the medullary cardiorespiratory center from mechanoreceptors and chemoreceptors in the lung and lower respiratory tract. Given the high similarity between SARS-CoV and SARS-CoV2, it is quite possible that the possible invasion of SARS-CoV2 is partly responsible for the acute respiratory failure of patients with COVID-19. The knowledge of this matter will have important guiding importance in the prevention and treatment of respiratory failure caused by SARS-CoV-2. (229 words)
Keywords
coronavirus; Cell sensitivity. Publishing | spread out Nervous system
Coronaviruses (CoVs), which are non-restricted positive-sense RNA viruses, commonly cause enteric and respiratory diseases in animals and humans.
1. Most human CoVs, such as hCoV-229E, OC43, NL63, and HKU1, cause mild
respiratory diseases, but its global outbreak by two previously unrecognized viruses, SARS-CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), has drawn global attention to the lethal potential of human CoVs 2 . While MERS-CoV has not yet been eradicated from the world, another highly pathogenic CoV, currently named SARS-CoV-2 (formerly known as 2019-nCoV), has It appeared in Wuhan, China in December 2019. CoV has this novel
It caused an outbreak of severe pneumonia (COVID-19) in China and spread rapidly around the world.
Genomic analysis shows that SARS-CoV-2 is in the same Betacoronavirus clade as MERS-CoV and SARS-CoV and shares highly homologous sequences with
SARS-CoV 3. Public evidence suggests that COVID-19 has a similar pathogenesis
With pneumonia caused by SARS-CoV or MERS-CoV 4. In addition, entry of SARS-CoV-2 into human host cells has been identified to use the same receptor as SARS-CoV 5 , 6 .
This post is written by Farshadboy000