Identifying the relationship between brain blood vessel lesions and intestinal bacteria
Neurosafari A clinical study funded by the National Institutes of Health (NIH) reported the connection between gut microbes and the body’s immune system with a genetic disorder that can cause strokes and seizures.
According to Neurosafari, citing the news site of the National Institute of Neurological Disorders and Stroke (NINDS), a study conducted on mice and humans shows that the bacteria in the stomach can affect the structure of the blood vessels in the brain and may cause structural abnormalities that cause stroke or seizures.
This research, which has been published in the journal Nature, is part of a series of emerging researches that have linked diseases of the nervous system to gut microbes. This study was funded by the National Institute of Neurological Disorders and Stroke (NINDS) as part of the NIH.
Cavernous cerebral malformations (CCMs) are clusters of dilated blood vessels with thinned walls that can cause seizures or strokes when blood leaks into surrounding brain tissue. A team of scientists at the University of Pennsylvania investigated the mechanisms that cause the production of CCM lesions in the brains of genetically engineered mice; And then they found an unexpected connection with a bacteria in the stomach. When the bacteria were eliminated, the number of lesions was significantly reduced.
Dr. Jim I. “This study is very exciting because it shows that changes in the body can affect the rate of progression of diseases caused by genetic mutations,” said Koenig, director of the program at NINDS.
The researchers were studying a mouse model in which a significant number of CCM lesions were formed in the brain after the injection of a drug (to create gene deletion conditions). However, when this animal was moved to another laboratory, the frequency of brain lesions dropped to almost zero.
Dr. Mark L. “It was like a puzzle,” said Kahn, a professor at the University of Pennsylvania School of Medicine and senior author of the study. Quite suddenly, the brain of our trusted animal model (mouse) was no longer able to produce CCM lesions, as previously expected. It is interesting that this variability is also seen in the formation of CCM lesions in the human brain; So that patients with similar (same) genetic mutations often have significantly different paths in the progression of the disease.
While researching this sudden change, Alan Tong, a graduate student in Dr. Kahn’s lab, observed that . https://goo.gl/o36aG9
Join the Neurosafari brain and neuroscience Telegram channel:
https://telegram.me/joinchat/CihxzDwTa19DOIUZRYLVjw
This post is written by neurosafari