Due to possible neurotransmission of SARS-CoV-2, antiviral treatment should be administered as soon as possible to block its entry into the CNS. Airway inhalation of antiviral drugs will be the first choice at the initial stage of infection, which will inhibit the replication of SARS-CoV-2 in the respiratory tract and lungs and prevent its subsequent neurodegeneration. It is also necessary to find effective antiviral drugs that can cross the blood-brain barrier. In addition, corticosteroids, which are frequently used for severe patients, may have no cure, but accelerate the replication of the virus in neurons.
Because SARS-CoV2 may hide itself in nerve cells from immune system detection, even recovery from acute infection may not ensure complete clearance of the virus. In support of this, there is evidence that SARS-CoV-2 is detectable in some patients during the congestive period 43 .
Therefore, due to possible neurogenesis, the risk of SARS-CoV-2 infection may be currently underestimated.
Resources
1Glass WG, Subbarao K, Murphy B, Murphy PM. Host defense mechanisms following acute respiratory syndrome-coronavirus (SARS-CoV) murine pulmonary infection. J Immunol 2004; 173: 4030-4039.
2Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W , Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical characteristics of patients infected with the 2019 novel coronavirus in Wuhan, China. . Lancet 2020; 395: 497-506.
3Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures to diagnose and treat infection by a novel coronavirus responsible for an outbreak of pneumonic pneumonia originating in Wuhan, China. Germs Infect 2020; pii: S1286-4579 (20) 30025-3.
4Song Z, Xu Y, Bao L, Zhang L, Yu P, Qu Y, Zhu H, Zhao W, Han Y, Qin C. From SARS to MERS, the ways of focusing on coronaviruses. 2019 viruses; pii: E59. doi: 10.3390/v11010059.
5Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Fhan Zhan, Wang L, Hu T, Zhou H, Hu Z , Zhou W, Zhao L, Chen J, Meng
Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W. Genomic and epidemiological description of 2019 The novel coronavirus: implications for virus origin and receptor binding – Cypress, Lancet Science Club 2020; in the press. pii: S0140-6736 (20) 30251-8.
6Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by a novel coronavirus from Wuhan: an analysis based on multi-year structural studies of SARS. J Virol 2020; pii: JVI.00127-20.
7Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal a dynamic receptor binding domain. Nat commun 2017; 8: 15092.
8Hulswit RJ, de Haan CA, Bosch BJ. Protein Proteins and the Tropical Variation of the Coronavirus Spike. Adv Virus Res 2016; 96: 29-57.
9Li YC, Bai WZ, Hirano N, Hayashida T, Hashikawa T. Coronavirus infection of mouse dorsal root ganglion: ultrastructural characterization of virus replication, transduction and rapid response of satellite cells. Virus Res 2012; 16: 628-35.
10Li YC, Bai WZ, Hirano N, Hayashida T, Taniguchi T, Sugita Y, Tohyama K, Hashikawa T. Tracking of a neurotropic virus reveals a membrane-mediated mechanism for transsynaptic communication. J Comp Neurol 2013; 521: 203-212.
11 Li K, Wohlford-Lenane C, Perlman S, Zhao J, Jewell AK, Reznikov LR, Gibson-Corley KN, Meyerholz DK, McCray PB Jr. Coronavirus Respiratory Syndrome Causes Multiple Organ Damage and Fatal Disease in Mice Transgenic for Human Dipidyl Peptidase 4. J Infect Dis 2016; 213: 712-722.
12Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot PJ. Axonal transport enables neuron-to-neuron transmission of human coronavirus OC43. J Virol 2018; 92: pii: e00404-18.
13Khan S, Ali A, Siddique R, Nabi G. Novel coronavirus puts the whole world at risk. J Hosp Infect. 2020; pii: S0195-6701 (20) 30043-8.
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