Due to possible neurotransmission of SARS CoV 2, antiviral treatment should be administered as soon as possible

Due to possible neurotransmission of SARS-CoV-2, antiviral treatment should be administered as soon as possible to block its entry into the CNS. Airway inhalation of antiviral drugs will be the first choice at the initial stage of infection, which will inhibit the replication of SARS-CoV-2 in the respiratory tract and lungs and prevent its subsequent neurodegeneration. It is also necessary to find effective antiviral drugs that can cross the blood-brain barrier. In addition, corticosteroids, which are frequently used for severe patients, may have no cure, but accelerate the replication of the virus in neurons.

Because SARS-CoV2 may hide itself in nerve cells from immune system detection, even recovery from acute infection may not ensure complete clearance of the virus. In support of this, there is evidence that SARS-CoV-2 is detectable in some patients during the congestive period 43 .

Therefore, due to possible neurogenesis, the risk of SARS-CoV-2 infection may be currently underestimated.

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