#clinical_tips
Clinical abnormalities resulting from changes in blood pH
In mammals, the pH level of various aqueous environments that are demarcated inside and outside the cell are different and have a constant dynamic state, so that the stable state changes in each of them, in other parts as well. It changes.
The blood pH value reflects the change in tissue pH, and values higher and lower than the normal range of pH, which are in the range of 7.35 to 7.45, indicate prone to damage.
Values less than 7 or more than 7.8 blood pH are part of a life-threatening condition and require immediate clinical action.
Many clinical conditions can cause significant deviation of PH
The blood will return to normal.
If the pH of the blood falls below 7.45, a condition called acidosis occurs, and if it reaches above 7.45, a condition called alkalosis occurs.
The states of acidosis and alkalosis are mostly defined based on the increasing source of acid or base in the body, which itself depends on metabolic or respiratory changes.
Metabolic acidosis may be due to excessive production of organic acids such as lactic acid or ketone bodies or a lack of HCO3 in the body.
Excessive production of acids may occur in diabetes, hypoxia (such as excess lactic acid production in distance runners
long) and the metabolism of acid-producing xenobiotics occurs.
HCO3 deficiency, which causes a change in acid and base balance, occurs in severe diarrhea, uremia, and acute kidney diseases.
Respiratory acidosis occurs when the retention of CO2, which is the anhydrous form (anhydride) H2CO3, increases in the body.
The causes of increasing the amount of CO2 include conditions that limit the exhalation of CO2 from the lungs due to the accumulation of fluids in the lungs due to emphysema or asthma, the occurrence of respiratory obstruction due to trauma, polyomyelitis and excessive obesity.
The main causes of metabolic alkalosis are an increase in HCO3 and eating bases.
Respiratory alkalosis is caused by hyperventilation (increased ventilation) related to seizures, high consumption of some drugs (such as salicylate) and fever.
Measuring blood pH to check the acid-base status is a common method in the treatment of many diseases, because an uncontrolled increase or decrease in blood pH can lead to serious and irreparable consequences.
This post is written by jm30303030