Corona virus deactivates the angiotensin convertase enzyme.
(Effect of virus like captopril poisoning)
Some interesting facts about Corona
(taken from the research results of the Texas Heart Institute, America)
Viruses of the corona group are not like influenza, which normally and biologically, with continuous changes of surface antigens, cause escape from the previous memory of the human immune system’s encounter with the virus. So far, there have been 3 attacks of the group of coronaviruses: Sars, MERS and now the new corona.
Interestingly, each of these viruses have found specific internal changes in their genomes that are completely suspicious and not a normal biological process.
The new virus has a genome that disables the famous ACEII enzyme, that is, in addition to the damage caused by the virus’s attack on the cells of the respiratory tissue and the involvement of the immune system and related reactions as normal, which is the behavior of the virus itself, the ACEII enzyme in the cells with this enzyme, which often In the vessels of the lungs, heart and kidneys, it fails, as in the case of overdose and poisoning with very high amounts of drugs such as captopril and enalapril. Due to its function, the failure of this enzyme will not convert angiotensin I to angiotensin II, also because this enzyme is responsible for the breakdown of bradykinin, the level of bradykinin will increase. This substance is a strong vasodilator as well as respiratory system stimulant and cough attack stimulant.
Therefore: in addition to all the natural damage caused by the virus attack on the body, another strange damage happens: the failure of the angiotensin-converting enzyme. Probably, vasodilatation caused by the lack of production of angiotensin II as well as the accumulation of bradykinin is the cause of blood pressure drop in vital organs such as kidney (increased urea and creatinine) and lung involvement in the form of interstitial and finally alveolar edema as well as heart failure.
Since there is no effective antidote for poisoning with ACEII inhibitor drugs, and only normal saline is used to maintain blood pressure within the normal range, there is no other way to save the patient’s life except supportive measures, which are usually ineffective.
Perhaps, in order to reduce the damage of vital organs such as lungs, heart and kidneys, the use of vasoconstrictor drugs such as vasopressin and high dose dopamine and norepinephrine as a continuous infusion from the time of diagnosis and the onset of symptoms of pulmonary and systemic involvement in the patient is effective, but it is still scientifically confirmed. Not in this case!
⁉ Now the question is how the corona virus (which is large in terms of size and size and it is easier to carry out experiments and biological changes in it) despite the fact that it normally does not have continuous genome and genetic changes, during the last two decades, such unusual behaviors It has shown itself to be normal and the recent virus also, completely abnormally, has changes that target and deactivate a very important and vital enzyme in the body???!!!
(Researchers should answer this question if taking drugs related to ACE is a risk factor or not!)
It is worth noting that:
In numerous research articles on diabetic proteinuria, vitamin D3 consumption helps the protective effect of ACEI drugs such as captopril and enalapril by inhibiting the renin-angiotensin system.
Biochemical basis of Corona
This post is written by Namo27