laboratory_criteria
Before examining the raised case, I will give an explanation, maybe many people will say what is CPK-MB and troponin???
Look, friends, CPK has three types of isozymes, including CPK-MM, which is present in skeletal muscles
The second is CPK-MB, which is found in the heart muscle
The third is CPK-BB, which is present in brain tissue.
Well, now let’s talk about CPK-MB, it’s time to introduce it:
It is a specific isoenzyme of the heart tissue that is found only in the cells of the heart muscle. Now, friends, if there is damage to the heart muscle cells, the level of this isoenzyme increases.
It is one of the most sensitive and reliable cardiac enzymes for diagnosing myocardial infarction.
Of course, friends, it also increases in severe angina.
Compared to other enzymes, this isozyme increases in the blood after infarction, and its increase is directly related to the size of the damaged area.
3-6 hours after the infarction, its level increases
12-18 hours later, it reaches its maximum level and returns to its normal level within 3-4 days.
Let’s introduce myoglobin. What is myoglobin?
There is also a protein that helps transport oxygen
Myoglobin is found in cardiac skeletal muscle
Children, myoglobin is quickly released from damaged myocardial tissue within 1-2 hours
It reaches the maximum after 6-12 hours
It will return to normal after 24 hours
Guys, please note that myoglobin is not specific in the diagnosis of myocardial damage, but if its level is normal, it helps to rule out the diagnosis of myocardial infarction.
Note:
Friends, if the result of the first myoglobin test is negative, the test will be repeated after 3 hours. If the result of the second test is negative, we can definitely say that the patient did not have a myocardial infarction.
Well, let’s go to the introduction of troponin:
It is a protein that exists in the myocardium
It plays a role in myocardial contraction
Troponin has three types of isomers (C, I, and T).
Troponins (I and T) are specific for the heart muscle
Between these two troponins, troponin type I is more specific and a more sensitive indicator for diagnosing acute myocardial infarction.
The point of this type I troponin is not affected by any other disease except heart damage
Because the level of troponin, especially type T, can be determined within a few minutes at the bedside, as a result, measuring troponin is commonly used in cardiac emergency in the first few hours to diagnose myocardial infarction.
Troponin type (T and I) increased about 3-4 hours after myocardial infarction
After 24-4 hours it reached the maximum
And after 1-3 weeks it will return to normal
Note:
Troponin also increases in unstable angina https://t.me/joinchat/LGFNuFbsiWDOnIal9Q65LA
This post is written by deture