#Question_of_your_friends
Hello, good time
Can you tell me in what conditions do we see polychromagia? And why is it seen in babies, babies who don’t have it usually
Hello, have a good time
In Bon Mero, after the ortho stage, we have Retic
As you can see, there are four types of rhetoric:
Type 1: Filamentous (string) thick
Type 2: narrow filamentous
Type 3: string and a little granule
Type 4: It has total granules
Normally, we see type 3 and 4 reagents in the peripheral blood, and we count exactly the same in BCB staining.
As a result of a series of events, Retic 1 and 2 also go to blood
The fact is, when you say that I saw polychromagia, you actually saw Retic 1 and 2! So, he may have hemolytic anemia, but polychromagia is not seen!
Before going to the main point, many people believe that polychromagia is always hemolytic anemia!
1) Myelophytic anemia: For example, a breast tumor has metastasized to the bone marrow and you see leukoerythroblastosis in the blood. My question is, in this phenomenon, do not immature cells enter the blood? Is it not considered immature cells?!
2) Extramedullary hematopoiesis, for example, liver and spleen
In thalassemia major, MMM and.
3) Treatment of anemia, for example, deficiency of iron, folate, etc.
4) Acute bleeding, such as surgery, trauma, accident, etc.
5) Severe hemolytic anemia, so it may not be seen in mild to moderate hemolytic anemia, but when you do retic staining, the percentage of retic is high 2%! These are the same type 3, 4 type
7) have a physiological increase in erythropoiesis
For example, whether the party is a smoker or polycythemia.
This is from the first answer
What kind of baby do you mean by baby?
Because in the texts, the baby has two definitions
A newborn baby is called a newborn
Well, in this situation, HbF>HbA1 is still there, and one of the characteristics of HbF is that it is stingy in releasing oxygen, and this causes the hemoglobin separation diagram to shift to the left, and the baby suffers from hypoxia, and what happens is that EPO is secreted from the kidneys and goes to the bones. It has an effect and as a result, erythropoiesis occurs and we witness polychromagia. This condition is called physiological polycythemia. According to Henry, there is only one period of a normal person’s life when RBC, MCV, MCH, Hb, HCT and retic have the highest values, this is the newborn period.
In general, morphological changes can be seen in term babies up to ten days
A baby whose birth months have passed is called an infant
Well, in an adult, HbA1>HbF, and exactly at 4-6 months, we have an isotype switching, which means that the gamma chain is replaced by beta and HbA1 is formed, and that’s why we have a physiological anemia at this time, and at the age of two years, HbF<1% and HbA1=97%.
P.N.: In the photo that explains the types of hemoglobin, there is a typographical error in the reference of Hoffmann
HbA = alpha two + gamma two
Gamma should be corrected by beta
This post is written by Amer_7798
